Do you know about - Are You Getting Your Carnitine?
Alpha Lipoic Acid Weight Loss! Again, for I know. Ready to share new things that are useful. You and your friends.Carnitine, also known as L-carnitine is an amino acid responsible for converyance of fatty acids into a cell's mitochondria. It is often sold as a nutritional supplement.
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We had a good read. For the benefit of yourself. Be sure to read to the end. I want you to get good knowledge from Alpha Lipoic Acid Weight Loss.Like all other proteinogenic amino acids natural carnitine is the L-stereoisomer. It can be synthesised within the body from the amino acids lysine or methionine. Vitamin C (ascorbic acid) is vital to the synthesis of carnitine. It has been speculated that while growth or reproduction the requirement of carnitine could exceed its natural production.
Role in fatty acid metabolism Fatty acids must be activated before they can be carried into the mitochondria, where fatty acid oxidation occurs. This process occurs in two steps:
1. However, pyrophosphate is hydrolized by a pyrophosphatase, which drives the reaction forward, and to completion.
Once activated, the acyl CoA is conveyable into the mitochondrial matrix. This occurs via a series of similar steps:
Acyl CoA is conjugated to carnitine by carnitine acyltransferase I placed on the outer mitochondrial membrane Acyl carnitine is shuttled inside by a translocase Acyl carnitine is converted to acyl CoA by carnitine acyltransferase Ii placed on the inner mitochondrial membrane It is importnat to note that carnitine acyltransferase I undergoes allosteric inhibition as a consequent of malonyl CoA, an intermediate in fatty acid biosynthesis.
Natural sources The best source of natural carnitine is in red meat and dairy products. Other natural sources of Carnitine comprise nuts and seeds (e.g pumpkin, sunflower, sesame), legumes or pulses (beans, peas, lentils, peanuts), vegetables (artichokes, asparagus, beet greens, broccoli, brussels sprouts, collard greens, garlic, mustard greens, okra, parsley), fruits (apricots, bananas), cereals (buckwheat, corn, millet, oatmeal, rice bran, rye, whole wheat, wheat bran, wheat germ) and other 'health' foods (bee pollen, brewer's yeast, carob, kale).
Acetyl-L-carnitine section references: [1]
AcetylcarnitineAcetyl-L-carnitine or Alcar, is an acetylated form of L-carnitine. Alcar is far first-rate to normal L-carnitine in terms of bioavailability in that it is absorbed by the gastrointestinal tract, enters cells and crosses the blood-brain wall more easily than unacetylated carnitine.
Alcar has a broad range of uses including blend with alpha lipoic acid to comprise a patented formulation that has been evidenced to "rejuvenate" the mitochondria of aging mice in studies conducted by Bruce Ames and others. Accordingly, acetyl-L-carnitine has potential as a life prolongation supplement probably capable of enhancing the quality and possibily also extending the mean life-span of humans. Other attributed uses for Alcar comprise using it as a medicine for depression (250 mg per day for any weeks) and for clearing plaque/fatty deposits out of the veins and arteries.
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